But that may be a "substantial underestimation," the study's authors wrote, because many incidents are never made public.
This results in substantial underestimation of PVPI.
However, neglecting to account for ageing error in natural mortality rate estimates resulted in a substantial underestimation of reference points.
Indeed, we provide simulation results for stratified simple random sampling showing that the use of design bootstrap weights may lead to substantial underestimation of the total variance, even when finite population corrections are ignored.
The influence of noise in the data is especially relevant for the estimates of PBF: high noise levels (i.e. low CNR values) lead to a substantial underestimation and a significant loss of accuracy in the PBF estimates.
At SBR1 and SBR2, PSF as well as PSF + TOF led to substantial underestimation by all segmentation methods compared to 3D-OSEM, 3D-OSEM + TOF, FBP, and FBP + TOF with lowest mean MTV deviations for t40.
In spite of this fact, it may lead to substantial underestimation of total gas extraction (Figure 15): about 20% for high-intensity (curves 1 and 2) and 34% for low-intensity gas production (curves 3 and 4).
While a signal void of 0.5 cm did not cause any significant change (−0.1%), 5 cm led to substantial underestimation of tumor activity of −33% in our selected case (Figure 4).
An optimized MRI sequence design can reduce these artifacts significantly [14] and thereby improve diagnostic accuracy and also reduce artifacts for MR-based attenuation correction (AC), since large signal voids can lead to substantial underestimation of FDG uptake within the area of the artifact when MRI-based AC is performed [22].
Thus, unknown or variable losses in volatile anesthetic content can lead to substantial underestimation of anesthetic efficacy.
However, this variable may also result in substantial underestimation of the importance of glycemic control, as the updated mean value of HbA1c gives equal weight to all historical HbA1c measurements.
