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The phrase "substantial thickness" is grammatically correct and can be used in written English.
It is a common way to describe something that is thick and sturdy. Example: The walls of the old castle were built with substantial thickness, making them almost impenetrable.
Exact(6)
He believed, however, that the rings were a single solid disk with a substantial thickness.
XRF can detect heavy metals through a substantial thickness of papyrus.
The sand formation has all properties relevant to the objectives of this study such as dip, anomalously high formation temperature suitable for electricity generation, substantial thickness, and areal extent.
Results also highlight a requirement for better appraisal of the deposit extent, with observations of locations where the deposit is absent as important as those defining substantial thickness.
The tissue was easily discerned by HD-OCT and was of substantial thickness near the external junction between the keratoprosthesis device and the carrier corneal tissue.
Anodization of the titanium implant surface changes the chemistry and the topography of the native titanium surface, resulting in a substantial thickness of the titanium oxide, with a porous topography and with a complex structure at both micrometer and nanometer scales [ 2, 7, 29, 38].
Similar(54)
Single-wall segments consist of welded stainless steel plates with substantial material thickness.
An examination of the cores indicates that there is a close spatial relationship between the abundances of the microcrystalline and the finely crystalline dolomites: the microcrystalline dolomite developed on top of finely crystalline dolomite, reaching substantial thicknesses, and the presence and thickness of type 2 dolomite is related to the abundance of type 1 dolomite.
Underlying the sediments are substantial thicknesses of basalt lavas from the Columbia River Basalt Group.
The joint reinforcement and/or segment laminate symmetry did not have the significant effect on the flexural strength due likely to the substantial laminate thickness and as well as to small length-to-depth ratios.
The vacuum-assisted resin transfer molding (VARTM) process is used to fabricate large-scale composite structures that can have substantial laminate thicknesses.
Related(20)
noticeable thickness
high thickness
critical thickness
major thickness
remarkable thickness
large thickness
real thickness
great thickness
important thickness
vast thickness
extensive thickness
appreciable thickness
severe thickness
enormous thickness
considerable thickness
substantial grievance
substantial dispute
substantial break
substantial neglect
substantial traffic
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com