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In addition to its importance in administration and banking, London once was a substantial manufacturing centre.
In the first half of the 20th century it was also a substantial manufacturing centre.
These countries have the clout to demand greater access to the markets of industrialized nations because together they account for more than half the world's population -- and they also have substantial manufacturing centers of their own.
GSK's efforts have received extensive media attention, and, with its substantial manufacturing capacity and experience, the mammoth U.K.-based company is widely assumed to be in the lead.
Entry into these parts of the value chain should enable them to leverage their substantial manufacturing assets in interesting new ways, as they can work directly with customers to lower the hurdle of upfront cost.
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The country's substantial aluminium manufacturing sector has moved to using geothermal energy to power its smelting process, and natural resources are also used in the processing and production of salt, seaweed, pet food and fish farms and to heat the greenhouses that grow the island's fruit, vegetables and flowers.
Agriculture, including soybeans, corn, cattle and hogs, is still a major industry in South Dakota, but the state's economy is more diversified than it once was, with substantial health care, manufacturing and financial services sectors.
As one would imagine, there are substantial expenses and manufacturing constraints behind the scenes of large rocket launches.
The freeze-drying cycles developed using OCT FDM data, as compared with traditional light transmission freeze-drying microscopy (LT-FDM), resulted in a significant reduction in primary drying time, which could result in a substantial reduction of manufacturing costs while maintaining product quality.
"The data continue to show substantial declines in real activity in manufacturing, the sector reflected in the industrial production index and in real manufacturing and trade sales," the committee said in a report on Nov. 9.
Alcoa, for instance, has substantial downstream manufacturing operations, including an aluminum foil business.
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sustainable manufacturing
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serious manufacturing
prominent manufacturing
strong manufacturing
substantial grievance
substantial funding
substantial book
substantial neglect
substantial effectiveness
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