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The intranasal route of vaccine application targeting nasopharynx-associated lymphoid tissue may be more advantageous for certain infections, but only if successful stimulation is achieved without the use of toxic adjuvants that might reach the central nervous system.
In other words, at the time when the 'behavioral threshold' (Tβ) level of thermal stimulation is achieved, i.e. time tTβ = tR−Lβ, the flow of information transmitted by the nociceptors is sufficient to trigger the behavioral response at time tR.
Normal mouse islets do not secrete insulin when exposed to 3 mM glucose, whereas half-maximal stimulation is achieved at ~11 mM glucose (Hedeskov, 1980).
MOE stimulation is achieved by controlling airflow of volatile stimuli into the nostril (blue arrow), which access the MOE, and are eliminated through a tracheotomy.
Similar(56)
Thyroid-stimulating hormone (TSH) stimulation was achieved by withdrawal of thyroid hormone.
cThyroid-stimulating hormone (TSH) stimulation was achieved by hormone withdrawal (endogenous) or by injection of recombinant human TSH (exogenous).
Thyroid stimulating hormone (TSH) stimulation was achieved by abstaining from levothyroxine administration for a minimum of four weeks prior to radioiodine administration.
Synaptic stimulation was achieved with a computer-controlled constant current-isolated stimulator (STG1002; Multichannel Systems, Germany) and bipolar electrodes placed on the internal capsule.
Interestingly, this electrical field stimulation was achieved in a non-contact manner, and was non-cytotoxic.
Selective muscle stimulation was achieved by varying the stimulation configuration of the four active electrodes on the nerve to produce different muscle activation patterns.
Propofol and dexmedetomidine/placebo infusions were terminated when three endpoints (subjects were too sedated to hold a syringe, followed by loss of eyelash reflex, followed by loss of motor response to electrical stimulation) were achieved sequentially.
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