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Moreover, this increased stimulating capacity correlates with an enhanced CD8+ immune response in mice.

This 'lower' stimulating capacity might be the explanation for the lack of 'therapeutic' activity of this TLR4 ligand.

Furthermore, a single substitution of the proline for an serine residue at either p6 or p8 abolished the T cell stimulating capacity.

Thus, E2 can enhance the Th2 stimulating capacity of DC in vitro.

To further investigate the effects of the applied loading strategies on HD-derived MoDC, we examined their migratory and T cell stimulating capacity.

We evaluated BMDC function by antigen-presenting activity and stimulating capacity for cytokine production from responder T cells as previously described (Koike et al. 2009).

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Similar(49)

Conditoned medium of fibroblasts or desmoid was 5 × concentrated in centriprep tubes YM-10 (Amicon, Millipore Corp., Bedford, MA, USA) and passed through a filter with a 0.22  μm pore size, before testing its invasion-stimulating capacity.

The results show that SpeB-processed CXCL9 had lost all the receptor-stimulating capacity of intact CXCL9.

This protocol significantly reduced the TLR2-stimulating capacity of SFE, suggesting that lipopeptides are a major contributor to the intestinal pool of soluble TLR2 stimulants (Figure 5A).

Notably, because it is has been proposed that diverse ligands beyond lipopeptide- and LPS-based molecules may also contribute to signalling via TLRs [28], the TLR-stimulating capacity of each extract is expressed as a biological activity relative to that of a chosen standard lipopeptide, LPS or flagellin.

Several different mechanisms have been proposed to account for the endothelial NO-stimulating capacity of HDL (Fig 3).

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