Sentence examples for spine turnover from inspiring English sources

Changes in spine shape and wholesale spine turnover provide mechanisms for modifying existing synaptic connections and altering neuronal connectivity.

To further ensure reliability of analyses, all measurements of spine turnover and stability were carried out blind by two experimenters.

To further investigate the dynamics and mechanisms underlying these effects, and since in vivo imaging is precluded by the need of anesthesia, we performed repetitive confocal imaging of eGFP transfected CA1 pyramidal neurons in 2 3 weeks old hippocampal slice cultures, a model also showing a developmental regulation of spine turnover [24].

The activation of ADF/cofilin could increase actin dynamics and result in spine turnover.

Furthermore, spine turnover is increased in the adult cortex of NgR1 mutant mice (Akbik et al. 2013).

NgR inhibits dendritic spine turnover (Akbik et al. 2013), which could result from the inactivation of ADF/cofilin.

Acute loss of palmitoyl-LIMK1 markedly impaired spine actin turnover without affecting dendritic spine number.

Palmitoyl-LIMK1 is essential for normal spine actin turnover, activity-dependent morphological plasticity and long-term spine stability.

We next sought to identify functional consequences of impaired spine actin turnover, caused by loss of palmitoyl-LIMK1.

DOI: http://dx.doi.org/10.7554/eLife.06327.017 The failure of CCSS-LIMK1 to rescue effects of LIMK1 knockdown to control spine actin turnover, morphological plasticity and spine stability was striking because CCSS-LIMK1 is not absent from spines, only not enriched in spine heads.

In the adult rodent brain, a small fraction of dendritic spines undergoes a certain turnover with spines being newly gained or lost, while the majority of spines is stable over long periods of time [ 20, 25, 58, 63].