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Another often used approach, sometimes referred as on-resonance saturation, is chemical exchange spin lock (CESL), which employs a spin lock module similar to that used in T1-rho imaging [36 38].
In the 2D-1H-NMR theSY the receptor NMR signal was filtered during the 80 ms spin lock, resulting in a cleaner analysis of chemical shift perturbation.
Correlation spectroscopy (COSY) [54], total correlation spectroscopy (TOCSY), using the MLEV-17 pulse scheme for the spin lock [55], and nuclear Overhauser effect spectroscopy [56] experiments were acquired under identical conditions for all samples, using gradients for water saturation.
In the following series, different SL pulse durations (time of spin lock, TSL) are applied.
Spin lock fields of 1245 Hz at 600 MHz, 1140 Hz at 800 MHz and 1085 Hz at 900 MHz were calibrated by offset-dependent scalar coupling measurements [ 41].
Site-specific rotating-frame relaxation times, T1ρ(H), for each H nucleus directly bonded to an observed C nucleus, were measured with a Lee Goldburg (LG) spin lock and LG cross-polarization period to suppress H spin diffusion; the experiments used a short 0.5 ms LGCP time and included 62 106 kHz LG pulses in separate trials.
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Two titans of spin, locked in a fast-moving battle over a dead terrorist's smartphone.
We investigate theoretically and experimentally the role of broadening due to heteronuclear dipolar coupling in spin-1 nuclear quadrupole resonance pulsed spin locking.
First, excitation with a spatially varying B1 causes flip-angle artifacts and second, spin locking with an inhomogeneous B1 results in non-uniform T1ρ contrast.
A multiple-pulse pulse sequence of the so-called "Pulsed Spin Locking" (PSL) type was used to acquire the data.
The hex locked, fixed weight dumbbell or a spin locked dumbbell are good choices.
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