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Exact(4)
Next, we investigated the specificity of regulation by CD4pres in vivo.
However, such matches have a high false positive rate and cannot identify tissue specificity of regulation.
The specificity of regulation was further confirmed by the fact that Itch failed to alter the G1 cell cycle pattern as well as apoptosis when it is overexpressed with RASSF5AY24A (defective for Itch interaction).
Knowing the localization of Tm isoforms in relation to myosin isoforms at the level of single filaments and/or stress fibers would provide insight into the specificity of regulation.
Similar(56)
Different patterns of covalent attachment of ubiquitin to target proteins provide a further level of specificity to regulation of cellular processes by ubiquitination.
This requires methodologies to model the tissue specificity of gene regulation by inferring trustful context-specific networks.
The overlap of blood eQTL with Alzheimer's disease associated eQTL was lower than eQTL that showed no disease specific effects, suggesting the possibility of increased tissue specificity of genetic regulation of expression levels in individuals with Alzheimer's disease.
The tissue specificity of microRNA regulation is known only in some specific cases (e.g. see Table one in [ 58]) and a general methodology for target identification, tissue specificity of action and specific biological role of microRNA in the initiation and progression of most cancers remains an open problem.
Developing Cre-lines that target specific functional subsets may be important for understanding the regional specificity of BBB regulation.
As a control, neither the C5 nor the C1 peptide had any detectable effect on extracellular signal-regulated protein kinase (ERK) phosphorylation, thus demonstrating the specificity of the regulation.
However, evidence has accumulated supporting the specificity of Sp1 regulation.
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