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To assess specificity of regulatory elements to each exC, we permuted cluster membership 1,000 times amongst the set of 1,282 statistically significant probesets and repeated the transcription factor annotation.
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Such unique TCR restriction model will allow us to examine the functional characteristics and allospecific specificities of regulatory cells based on the inducing therapeutic agent.
The accessibility of proteins to A/T-rich sites on promoters of tissue-specific genes along with other factors will promote the comprehensive specificity of the regulatory process of functional genes in bone tissue.
We discuss the general principles of these interactions as well as the remarkable cell-type specificity of the regulatory mechanisms and their resulting immune responses.
Gene expression is a result of the interplay between the structure, type, kinetics, and specificity of gene regulatory interactions, whose diversity gives rise to the variety of life forms.
To confirm the specificity of the regulatory effects observed with TBHsp70 treatment, we repeated the graft experiments using different proteins.
We surveyed the marking specificity of 76 regulatory genes such as transcription factors and signal transducers.
In addition, in a subpopulation of n=40 participants (20 of each intervention arm) the specificity of FoxP3+ CD25+ regulatory T-cells is measured.
Such attributes include gene age, tissue specificity of expression, regulatory capacity, sequence length, rate of sequence variation and capacity for interaction.
In this way, negative auto-regulation may help to increase the input dynamic-range while maintaining the specificity of cooperative regulatory systems.
We have demonstrated that the identification of the molecular specificity of a regulatory element can be of great help in solving notoriously difficult annotation issues, e.g. by defining the substrate specificity of genes encoding amino acid transporters on basis of the amino acid specificity of the regulatory T-box.
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