Sentence examples for soft endpoints from inspiring English sources

There is a lack of robust or operational biomarkers to substitute for soft endpoints.

These studies only tested soft endpoints, meaning cholesterol changes from baseline and not clinical outcomes of the treatment.

For example, in recent debates over first line antihypertensive drugs metabolic effects (soft endpoints), not hard end points, have been at the centre of the debate.

Revision stabilization is defined as the hard endpoint of the register, whereas soft endpoints are patient-reported recurrences of instability and WOSI score at follow-up.

Moreover, we have argued elsewhere that even low behavioral effects may provide soft endpoints of neurotoxicity that could incur considerable economical costs (loss of work efficiency or motivation) when a large population is affected across an extended time span [ 53].

Anterior drawer and Lachman tests are usually positive, with either a soft endpoint or no endpoint due to the ACL injury.

Presence of a mushy or soft endpoint when the tibia was moved forward on the femur was considered as positive [19].

In the present study, 91% of patients in the validation study had no acute coronary syndrome-defining event within 30 days of initial evaluation (including the "soft" endpoint of revascularization).

A difference of >3 mm in anterior tibial translation as compared to the uninjured, contralateral knee as well as a soft endpoint indicate a positive Lachman test, which is indicative of injury to the ACL, both in the AM and PL bundles [ 15].

This approach has been applied in a number of previous twin studies investigating different health outcomes, including mortality, 21 hospitalisations, 22 breast cancer 23 and also softer endpoints such as depression scores and self-rated health.

However, it appears that this composite endpoint included the softer endpoint of TIA in addition to stroke and mortality.