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However, as serious increase in AUC and phospholipidosis (PLsis) were observed in its toxicological studies in rats, follow-up compounds were searched to avoid risk of PLsis with reference to their in vitro PLsis potentials evaluated on the basis of accumulation of phospholipids in HepG2 cells exposed to the compounds.
Simultaneously, the references of extracted articles were also manually searched to avoid missing relevant studies.
In order to address these problems, the derivative is used to find the local minima and a larger neighborhood is searched to avoid small noisy minima.
No terms relating to the 'comparison' and 'outcome' of trials were searched to avoid excessive exclusion of trials in an area where limited research has been conducted.
The detailed search strategies for MEDLINE are presented in online supplementary appendix 1. Bibliographic references in relevant publications (eg, anaesthesiology and pain medicine textbooks, other review articles and included clinical trials) will be manually searched to avoid missing eligible trials.
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Far from searching to avoid death "at any cost" irrespective of the ensuing living conditions, the primary goal of intensive care is to return the highest number of critically ill patients to a quality of life they would find acceptable [1].
The strengths of this study lay in the broad search terms that we used to retrieve literature, including hand searching to avoid missing available literature and also checking reference lists of included studies.
Far from searching to avoid death "at any cost" irrespective of the ensuing living conditions, the primary goal of intensive care is to return the highest number of critically ill patients to a quality of life they would find acceptable [ 1].
But by investing so exclusively in the protean figure of Wergeland, the restless innovator whom we are only allowed to admire, Kjaerstad proves that the search to avoid cliché is often the route to it.
We therefore did not adopt the citation-based method in our literature search to avoid discriminating against recent papers.
Na was analyzed for 10 s (background: 5 s) without a peak search to avoid count loss.
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