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Preventing the generation of self-reactive memory B or long-lived plasma cells is another important peripheral checkpoint to avoid autoimmunity.
Germinal center exclusion of self-reactive B cells (9G4 B cells) that express self-reactive antibodies encoded by the IGVH 4-34 gene is an important peripheral checkpoint to avoid the interaction of autoreactive B and T cells, with the subsequent generation of autoantibodies.
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Thus, if this process is to be effectively manipulated in order to release the brake, we have to stimulate APCs with an antigen significantly different from "self" to recruit effector cells, balance cytokines to obtain a pro-inflammatory milieu, and finally, inhibit immune checkpoints to avoid tolerance.
A tight cell cycle DNA damage checkpoint helps to avoid DNA damage being transmitted to daughter cells [17].
If you miss the Flood, quickly revert to last checkpoint in order to avoid restarting the whole campaign level again.
While some immune checkpoints are engaged to avoid immune-mediated eradication, others are merely a part of the normal immune response to stimuli.
Similarly, Mdc1 has also been suggested as a substrate of Cdk1, and Cdk1-dependent regulation disrupts Mdc1 and γ-H2AX interaction, presumably to avoid checkpoint activation during mitosis [ 55].
To avoid checkpoints, drivers walk their motorbikes across the thin, shallow waters of the Táchira river that serves as the border between the two countries.
To avoid checkpoints, smugglers were taking unfamiliar routes and abandoning their passengers when they spotted what appeared to be a military convoy on the horizon.
After what he described as a 15-hour trek through the mountains, taking back roads to avoid checkpoints, Mr. Zelaya and his wife took refuge at the Brazilian Embassy in Tegucigalpa, the Honduran capital.
The number of aircraft in the sky and checkpoints they were told to avoid made the abductors nervous.
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