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However, the post-operative subconjunctival scarring response which blocks filtration efficiency is a major hurdle to the achievement of long-term surgical success.
Replacing photoreceptors is much more challenging than RPE cells because the connection between photoreceptors and neurons are lost, and also because of the potential scarring response elicited.
The acute scarring response differed significantly in the two placements considered.
The scarring response following injury to the central nervous system disrupts the anatomical organization of nervous tissue posing a barrier to the regeneration of axons.
To limit the post-operative scarring response, physicians often employ anti-proliferative agents to improve surgical outcomes.
Current application of anti-proliferatives to modulate the scarring response is not ideal as these often give rise to sight-threatening complications.
Similar(54)
Scarring in response to wounding occurs in skin, but not in the oral cavity [1].
The materials were implanted devoid of cells; they provoked a minimal scar response by the host tissue and permitted the invasion of neurons and glia inside them.
PPD response (yes/no) and scar response (yes/no) were analyzed as prevalence data using a Poisson regression model with robust variance estimates providing prevalence ratios (PR) [11].
Two studies concluded that combination therapy led to improved scar response than individual treatments.
We do not rule out that miR-125b could target other genes that might be involved in the glial-scar response.
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