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In such situations, the prognosis remains uncertain unless retrospective dose quantification is performed within appropriate regions of interest.
Gamma doses were predicted from the beta responses, to evaluate the effectiveness of retrospective dose evaluation for different signal integrals, preheat combinations, and dose intervals.
Retrospective dose quantification of 90Y resin microspheres was performed on the same 23-patient data set in part 1. Phantom studies were performed to assure quantitative accuracy of our time-of-flight lutetium-yttrium-oxyorthosilicate system.
Higher preheats, up to 300 °C, preferentially removed OSL and TTOSL signals evident at longer stimulation times: those that remained yielded growth in signal with dose to approximately 10 kGy, but the accuracy of retrospective dose determinations was variable.
For retrospective dose estimation specialized radioecological data were necessary.
The approach and software used for retrospective dose evaluations has been previously detailed in Diallo et al. (1996, 2009).
Similar(48)
Retrospective doses may be more difficult to estimate because of the fairly rapid time-dependent loss of "stable" aberrations in blood lymphocytes.
We performed a retrospective dose-volume-outcome analysis for the TL in NPC patients treated with IMRT.
From a clinical perspective, this means that if tumor predictive dosimetry had been applied to a technically successful 90Y radioembolization under near-ideal dosimetric conditions, then the intended tumor mean doses may be assumed valid and retrospective tumor dose quantification is usually unnecessary, unless for research or quality assurance.
For retrospective acquisitions, dose modulation is used to minimise radiation dose.
However, in technically unsuccessful90Y radioembolization, we feel that retrospective tumor dose quantification by 90Y PET may be routinely indicated because the intended tumor doses by predictive dosimetry may have become invalid.
Related(20)
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