Even if someone has taken penicillin in the past, there is no guarantee that they will not become allergic to penicillin with a subsequent dose.
The subsequent dose calculation was performed using the adult male model of the software OLINDA.
For administration in divided doses, it is also necessary to administer the subsequent dose after a sufficient period of observation.
The typical dosage of valproate is 1,000 mg ×1 and in some cases a subsequent dose adjustment to 500 1,800 mg ×1 [10].
This tumor was harvested from a mouse treated with a priming administration (2.5 MBq) followed by a subsequent dose (12.5 MBq) of 177Lu-octreotate 24 h later.
Subsequent dose escalations of melphalan were done at 20 mg/m2 increments up to a maximum dose of 280 mg/m280
Such a vaccine could be used to provide at least some minimal level of H5N1 protection on its own and/or prime for a subsequent dose of a more traditional but supply-limited vaccine.
Cumulative cytotoxic effects of l-OHP delivered by PEG-coated cationic liposomes led to deep diffusion of a subsequent dose of liposomal l-OHP in solid tumor presumably as a result of the enlarged intra-tumoral interstitial space.
This led us to assume that prior dosing with liposomes might enhance the intra-tumoral accumulation of a subsequent dose, and hence improve the therapeutic efficacy of entrapped l-OHP.
or treated with lead acetate for seven days (1st dose: 4 µg/100 g, subsequent dose: 0.05 µg/100 g, i.m. to cover daily loss).
Time at risk was calculated from time of IPT treatment until completion of five months (150 days) of follow-up, receipt of a subsequent dose of IPT or exit from the study (emigration, death, refusal or exclusion), whichever occurred first.
