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But he and other experts caution that while the immortal cells retain growth controls in culture, they may still be predisposed to cancer in humans.
The LxCxE-binding-defective RB mutants retain growth suppression function because these mutants retain their interactions with E2F [10] [10].
Our findings show that, although many cancer cells lost sensitivity to the growth inhibitory effect of TGF-β1, only two murine cell lines underwent TGF-β1-mediated EMT and these cells retain growth inhibitory response to TGF-β1.
Moreover, xenografts of UCP2-overexpressing HCT116 colon cancer cells retain growth in nude mice receiving chemotherapy, providing strong evidence that UCP2 upregulation is a plausible mechanism of chemoresistance in such studies (Derdak et al, 2008).
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The grains are angular and poorly sorted with many minerals retaining growth forms that resulted from low abrasion.
In conclusion, the huscFv produced in this study revealed decreased immunogenicity while retained growth inhibitory effect on EGFR-overexpressing tumor cells.
Consequently, heparin microparticles present an effective method of delivering and spatially retaining growth factors that could be used in a variety of systems to enable directed induction of cell fates and tissue regeneration.
Transductants that lost growth also lost the lesion in nemR or sroG, whereas transductants that retained growth retained the lesion.
These results show that the RB-K or the RB-N mutant retains growth suppression activity, but the RB-KN mutant is defective in growth suppression, consistent with its defect in repressing transcription from the Cyclin A promoter (Fig. 2A).
The isolated distal axons retained growth cone structures in the absence of synaptic targets, and expressed glutamate receptor subunits.
Cell clones that stably expressed G418 and retained growth potential were assayed for BRCA1 expression by Western blot assay.
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