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As part of a large effort by the NASA Specialized Center of Research and Training in Advanced Life Support to reduce equivalent system mass (ESM) for food production in space, the dilemma of vine management for sweetpotato was addressed in effort to conserve growth area without compromising root yield.
In general, stem cells have a slow rate of turnover at steady state to conserve growth potential and prevent genetic injury during mitosis.
To conserve growth potential and prevent genetic injury during mitosis, stem cells cycle slowly and are recruited only as demanded by tissue turnover.
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Wnt proteins constitute a family of highly conserved growth factors [1] that mediate a wide range of biological processes, including proliferation, migration, and differentiation.
In addition to affecting mesenchymal cell biology, abrogation of mesenchymal Apc function also inhibited epithelial growth by disrupting multiple evolutionarily conserved growth factors, including Fgf and Bmps.
These are often members of conserved growth regulation pathways such as cell cycle, insulin signaling and apoptosis (Hafen and Stocker 2003).
Network analysis on these clusters identified evolutionarily conserved growth pathways (NOTCH, VEGF, TGFB, WNT and glucocorticoid receptor – Hyper-geometric test, q < 0.05).
A tissue-independent development-related minimal essential network derived from this interactome model was associated with the same evolutionarily conserved growth pathways identified in the main data set.
The key evolutionarily conserved growth pathways associated with a development-related gene expression in this study are involved in the aetiology and pathogenesis of childhood cancers e.g. TGFβ signalling in Wilms tumour [ 57] and Rhabdomyosarcoma [ 58].
These clusters of gene expression were examined in relation to an interactome model and shown to include evolutionarily conserved growth pathways (NOTCH, VEGF, TGFB, WNT) with high levels of 'connectivity' implying essential biological functions [ 16].
The presence of a set of evolutionarily conserved growth pathways associated with the phases of human growth and development in lymphoid tissue was validated by replication in an independent set of PBMC gene expression data from age-grouped normal children (Additional file 1: Tables S1 & S6).
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CEO of Professional Science Editing for Scientists @ prosciediting.com