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Thus, systemic IFN-γ may have dual roles in the UPEC infection, balancing the appropriate inflammatory response while restricting tissue damage.
Modulation of the CNS-resident inflammatory response of astrocytes via NF-κB interference, as shown here for LAQ, may represent a novel protective means of restricting tissue damage and neurodegeneration in demyelinating diseases.
The elevated IFN-γ serum levels observed may imply important dual roles for this cytokine in balancing the inflammatory response to clear the infection, while at the same time restricting tissue damage.
In addition to neutralizing all isoforms of TGF- β, DCN also binds and neutralizes another member of the TGF- β superfamily capable of inducing fibrosis and restricting tissue regeneration, myostatin [ 37, 40].
Substantial evidence supports a role for autophagy in prevention of tumorigenesis by maintaining genomic integrity and decreasing DNA damage,, restricting tissue necrosis and inflammation, and degrading specific proteins or organelles that otherwise would lead to aberrant signaling pathways and increased oxidative stress.
Similar(55)
Together with transcription factors, these complexes help dictate the transcriptional output of a cell and, thus, balance cell proliferation and differentiation while restricting tissue-specific gene expression.
Fruit-specific promoters with unique positive and negative regulatory elements may function efficiently in restricting tissue-specific expression of genes and avoiding the possibility of abnormal plant growth often observed with constitutive promoters.
QPRT enzyme activity has a restricted tissue distribution, although QPRT mRNA is expressed ubiquitously.
Cell sheet engineering thus presents several significant advantages and can overcome many of the problems that have previously restricted tissue engineering with biodegradable scaffolds.
Due to restricted tissue oxygenation, chronically hypoxic tumor cells frequently become necrotic and thus there is often an association between chronically hypoxic and necrotic tumor regions.
The mitochondrial ferritin is found in mammals, it has a restricted tissue distribution and it seems to protect the mitochondria from iron toxicity and oxidative damage.
Related(20)
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