restrained refinement

USAGE SUMMARY

The phrase "restrained refinement" is correct and usable in written English.
It can be used to describe a style or quality that is elegant and sophisticated but not overly ostentatious or extravagant. Example: "The interior design of the room showcased a restrained refinement, with subtle colors and minimalist decor that exuded class without being flashy."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

50 human-written examples

The structures were refined by cycles of maximum likelihood, restrained refinement with REFMAC5 with riding hydrogens and anisotropic temperature factors in the final cycles.

Biochemistry

Final cycles of the refinement were carried out by the maximum likelihood restrained refinement protocol of CCP4-Refmac [47].

Plosone

Further restrained refinement was carried out using REFMAC5 applying TLS parameters in the final rounds of refinement [65], [66].

Plosone

Iterative cycles of manual building in both Coot and O [37] and restrained refinement in REFMAC5 [38] were performed.

Plosone

After rigid body refinement and restrained refinement against a maximum likelihood function (MLF) with Refmac5, the Rwork and Rfree values were 0.31 and 0.41, respectively.

Plosone

Restrained refinement using TLS groups was carried out in Refmac and Phenix using NCS restraints.

Biochemistry

Human-verified similar examples from authoritative sources

Similar Expressions

10 human-written examples

Rigid body refinement, simulated annealing, energy minimization and restrained B-factor refinement were carried out using the program CNS (32), iteratively with manual rebuilding using O (33).

Biochemistry

Final rounds of model building for both the structures were carried out using COOT (Emsley and Cowtan, 2004) and refined using PHENIX (Adams et al, 2010) involving restrained maximum likelihood refinement of atomic position and isotropic B-factors.

EMBO Journal

Iterative structure refinement was carried out using a combination of CNS1.2 [42] and REFMAC5 [43] for simulated annealing, sigma A weighted composite omit electron density calculations, and restrained maximum likelihood refinement.

Plosone

This difference is due to a "tilt" of the nicotinamide rings in the structures determined previously, where crystallographic refinement restrained the planarity of the ring, or to ring puckering in this study, where no restraints on planarity were applied.

Biochemistry

To preserve A-form geometry in the stem II portion of the yPrp3CTF-yU4/U6stem II+10nt structure, an A-form duplex was used as a reference model and the A-form geometry was restrained during the refinement.

eLife

Expert writing Tips

Best practice

When describing scientific or technical processes, use "restrained refinement" to indicate a controlled and careful approach to improving accuracy and precision.

Common error

While "restrained refinement" is appropriate in scientific and technical writing, it may sound overly formal or pretentious in casual conversation. Choose simpler terms like "careful improvement" or "precise adjustment" for everyday use.

Linguistic Context

The phrase "restrained refinement" primarily functions as a noun phrase, often used as a subject or object in sentences describing scientific or technical processes. This is supported by Ludwig's examples, which showcase its use in describing model building and data analysis techniques.

Expression frequency: Common

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Academia

0%

Ludwig's WRAP-UP

In summary, the phrase "restrained refinement" is a grammatically correct and commonly used noun phrase, predominantly found in scientific and technical contexts. Ludwig AI confirms its usability in describing optimization and improvement methods with specific controls. When writing, it's best to use this phrase in formal scientific contexts and avoid it in casual conversation. Alternatives such as "controlled optimization" can be used depending on the specific context. "Restrained refinement" is frequently associated with domains such as structural biology and crystallography, indicating a meticulous and regulated approach to model building and data analysis.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

controlled optimization

Emphasizes the controlled aspect of the refinement process, focusing on achieving an optimal result.

precise adjustment

Highlights the accuracy and exactness involved in making corrections or improvements.

careful calibration

Focuses on the meticulous nature of the refinement, aligning it with achieving a standard or benchmark.

measured improvement

Suggests gradual and deliberate progress towards a better state.

judicious alteration

Highlights the use of good judgment in making changes or modifications.

tempered modification

Indicates that the modifications are moderate and controlled, avoiding extremes.

regulated tuning

Implies a fine-tuning process that is carefully managed and adjusted.

moderate correction

Focuses on making corrections that are not drastic or excessive.

disciplined enhancement

Highlights the structured and systematic approach to making improvements.

conservative amendment

Suggests a cautious approach to making changes or revisions.

FAQs

How is "restrained refinement" used in scientific research?

"Restrained refinement" is commonly used in structural biology and crystallography to describe the process of improving a model of a molecule by applying specific constraints and data. For example, iterative cycles of model building can be performed with COOT, and "restrained refinement" with REFMAC5.

What are some alternatives to using "restrained refinement"?

Depending on the context, alternatives to "restrained refinement" could include "controlled optimization", "precise adjustment", or "careful calibration".

In what contexts is "restrained refinement" most appropriate?

"Restrained refinement" is most appropriate in technical or scientific contexts, particularly when discussing processes involving data analysis, model building, or optimization. These scenarios demand a degree of precision where this term is commonly applied.

How does "restrained refinement" differ from standard refinement techniques?

"Restrained refinement" involves applying specific constraints or parameters during the refinement process, often to prevent overfitting or to incorporate prior knowledge about the system. This contrasts with unrestrained refinement, where the model is refined solely based on the experimental data.