Sentence examples for relevance of trail from inspiring English sources

Although we are aware that a limitation of this exploratory analysis is the relatively small sample size examined, which does not allow to corroborate the prognostic relevance of TRAIL as a biomarker, several possible mechanisms by which reduced TRAIL serum/plasma levels might contribute to worsen the outcome of AMI can be envisioned.

Furthermore, in HIV-infected human lymphocyte aggregate cultures containing pDC, antagonistic anti-TRAIL antibodies did not alter uninfected CD4+ T-cell death [10], thereby raising questions as to the true relevance of TRAIL in bystander killing.

The clinical relevance of TRAIL receptor (TRAILR -directed TRAILR -directeds emphasized by currentherapyes (see alsofHCCp://clisicaltrials.gov/ct2/show/study/NCT01258608).

Instead, it is important to perform differentiated analyses of the subcellular distribution of receptors for the understanding of both the molecular biology and the disease-related relevance of TRAIL death receptors, especially when conclusions on the impact of these receptors for disease prognosis are drawn.

We next investigated the relevance of TRAIL-mediated enhancement of APAP-induced cell death also in vivo.

To evaluate the in vivo relevance of TRAIL-mediated killing, tumor-bearing TRAIL-deficient mice were treated with CY and tumor growth in these mice was compared with immunocompetent mice.

A more recent study investigated the relevance of the OPG-TRAIL interaction using an in vivo murine model of bone metastasis 26.

To test the relevance of these genes as predictors of TRAIL-responsiveness, the sensitivity value (sensitive or resistant) of the cell lines was changed to the incorrect alternative in a randomly selected 50% of the samples and the accuracy of the model determined.

However, the relevance of upregulated DR5 expression for enhanced TRAIL DISC formation and stress-triggered sensitization of cancer cells to TRAIL-induced apoptosis is controversially discussed [41], [54], [55], as it may also result from an enhanced binding of caspase-8 to the DISC.

In addition, TRAIL-R1 (DR4) and TRAIL-R2 (DR5) were always expressed in vitro, although with different staining intensity (Supplementary Figure S1a), and the levels of expression of DR5 correlated significantly with responsiveness to TRAIL, indicating the relevance of such receptor (Supplementary Figure S1a).

Massachusetts has 90 mile of trail.