Sentence examples for importance of trail from inspiring English sources
Several studies have reported on the importance of TRAIL and TRAIL receptor expression in inducing or inhibiting apoptosis [ 13- 16].
The importance of TRAIL in intestinal cell differentiation has subsequently been demonstrated [11].
The importance of TRAIL was supported by experiments in nude mice where the lack of functional T cells could be compensated by agonistic anti-TRAIL-receptor (DR5) antibodies.
The importance of TRAIL suggests that TRAIL production by T cells or NK cells could be an important readout to predict the efficacy of cancer vaccines or immunotherapies, possibly equally important as perforin-mediated cell apoptosis and IFN-γ.
Although the biological importance of TRAIL is not completely understood, it appears that this protein may have a critical role in cellular response to environmental stress.
The importance of Trail as a tumour suppressor is supported by a number of results in different animal models including the onset of spontaneous haematopoietic malignancies in Trail KO mice [ 40].
Fundamental studies of the importance of trailing edge heat transfer to the design of an optimal cooling scheme are scarce.
Furthermore, given the importance of TRAIL-R2, we hypothesized that the use of TRAIL-R-specific variants that specifically induce apoptosis via TRAIL-R2 might increase the efficacy of the MSC.sTRAIL system further.
In order to solidify the importance of TRAIL-R4 expression and its connection to TRAIL resistance, another breast cancer cell line, MDA-MB-231, was also analyzed in terms of TRAIL receptor expression profile.
The importance of TRAIL-R levels in determining sensitivity or resistance is validated by changes in the TRAIL-R expression in response to chemotherapy, radiation, or steroids that are associated with increased responsiveness (Gong et al, 2006; Kouhara et al, 2007; Oikonomou et al, 2007).
A number of evidence highlight the importance of the Trail receptor pathway in tumour onset and development.
