Sentence examples for release of payload from inspiring English sources

It is always a challenge to control the release of payload for effective delivery to the site of interest.

The main mechanism for delivery was not by endocytosis of nanoparticles but by nanoparticle-cell contact-mediated transfer directly to the cytosol and, to a smaller extent, release of payload from nanoparticles into the medium followed by diffusion into cells.

Here we show that focused ultrasound, used at pressures similar to those applied during diagnostic ultrasound scanning, can be utilised to both trigger and monitor release of payload from liposomes.

Only 1.56% of administered drug molecules can enter target cells if the efficiency of each step in the ADC mechanism is assumed to be 50% (biodistribution, binding to antigen, internalization, release of payload, intracellular stability of payload, and payload binding to target) (Teicher and Chari, 2011).

The main mechanism of delivery was not via endocytosis of nanoparticles, but rather via nanoparticle-cell contact-mediated transfer directly to the cytosol and, likely to a smaller extent, release of payload from particles to the medium, followed by diffusion into cells.

Second, we have encased the recombinant symbiont in an alginate particle that inhibits release of payload into the environment.

The reduction of disulfide bonds in vivo has been widely applied for the release of payloads from drug delivery systems fabricated by chemical conjugation technologies.

It is even possible to formulate liposomes that are sensitive to a wide range of external stimuli, such as heat, light, ultrasound, and pH, to allow a highly controlled release of payloads [5].

The release of payloads from nanocomplexes (NCs) was shown to be limited at physiological pH (17.1 ± 2.8%) but significantly elevated at endosomal/lysosomal pH (58.4 ± 3.0%) and at enzymatic environment (81.4 ± 4.2%).

The special buildup of compactly clustering OEI600-PBA units around hydrophobic HBPO aggregate offered significant advantages over parent OEI600-PBA, including strengthened affinity to siRNA, ability of further loading anticancer drug, easier cellular transport, and acidity-responsive release of payloads.

An increase in the diffusion barrier could in fact provide a practical advantage in applications of these microgel particles where slow release of payloads carried within the porous mesh of the microgel is desirable.