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Our results demonstrate initial attempts to characterize the ROMP-triggered release of cargo peptides from P22 nanocontainers.
Lo, P. K. et al. Loading and selective release of cargo in DNA nanotubes with longitudinal variation.
The preferential release of cargo in acidic conditions provided enhanced transfection efficiency compared to non-degradable counterparts.
This powerful concept has been successfully applied to the fabrication of drug delivery schemes where the tissue of interest is targeted via release of cargo triggered by the biocatalytic action of an enzyme.
The results obtained here provide a rational basis for developing engineered R5 silaffin peptides into efficient tools for silica precipitation as well as for entrapment and release of cargo molecules under physiological conditions.
Transcytosis across the blood brain barrier involves a number of distinct stages, including receptor binding, endocytosis into a transport vesicle, trafficking of the vesicle to the opposite side of the cell, and finally exocytosis and release of cargo.
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Thermally expandable microcapsules (TEMs) with wrinkled shells are prepared by one-step suspension polymerization, allowing for encapsulation and controlled release of cargos.
However, in initial studies, release of cargos from these polymeric materials was entirely diffusion controlled.
We are still unsure of the pathways from agonist stimulation that could lead to the differential release of cargoes.
For example, light-switchable α-cyclodextrin (α-CD) and azobenzene interaction has been employed to control the viscosity of hydrogels, the release of cargos from carriers, and the assembly of macroscopic/microscopic objects.
To test our hypothesis that conjugating multiple cationic dendrimers on a nanoworm scaffold would enhance the proton sponge effect, leading to better cytosolic release of cargos, we evaluated the efficiency of dendriworm endosomal escape compared to free dendrimers.
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