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We created the Illinois CRE registry definition in accordance with the interim CDC definition proposed in the 2012 CDC CRE Toolkit (14 ).
Massive transfusion was defined as 5 or more units of red blood cells within 4 hours in accordance with the Australian Massive Transfusion Registry definition.
We found that outpatient physician claims identified patients receiving chronic dialysis with "substantial" agreement to a reference standard dialysis registry definition.
Abbreviations: prev - Prevalence = Admin /total N All four physician claims-based case definitions assessed resulted in "substantial" agreement with our reference standard registry definition for chronic dialysis.
The remaining two diabetes definitions included the definition proposed by the Ontario Ministry of Health and Long-Term Care in Ontario for the Baseline Diabetes Database Initiative (BDDI) to populate a provincial diabetes registry (Definition 2), and the previously validated ODD definition (Definition 3).
For the GP, hospital, and mortality registry, definition of a general respiratory syndrome was guided by the case definitions and codes found in the International Classification of Diseases, 9th revision, Clinical Modification (ICD-9-CM), as selected by the Centers for Disease Control and Prevention (Atlanta, GA, USA) (www.bt.cdc.gov/surveillance/syndromedef).
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The online supplement provides further description of the utilised registries, definition of drug exposure and covariates, and supplementary analyses.
Generally, previous studies are characterized by use of different gold standards in the assessment of the validity of registries, different definitions of relevant diagnosis codes to validate as well as varying use of diagnostic procedures (such as CT or MRI scans), all of which complicate direct comparisons of existing results.
However, using cancer registries as sampling frames meant we did not have baseline (ie, prediagnosis) HRQoL data as, by definition, registries do not record an individual's details until they have a cancer diagnosis.
The analysis of this registry used 2 definitions of compliance: one based on number of expected doses of palivizumab (eg, a patient receiving the first dose in November would be compliant if receiving 5 doses total) and the other including those infants receiving ≥2 doses of palivizumab who received all doses within 35 d of the previous dose.
The RHEOP registry uses the WHO definition of a stillbirth, i.e., "the birth of a baby with a birth weight of 500 g or 22 or more completed weeks of gestation who died before or during labor and birth" [ 14].
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