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As a concept multistage vaccine, we constructed a polyepitope by fusing five HLA-DR3-restricted T-cell epitopes derived from different Mtb proteins either expressed highly by replicating bacteria (Ag85B, hsp65, 19 kDa lipoprotein), or abundantly expressed by dormant bacilli and recognized preferentially by TST+ individuals (hsp16, Rv1733c).

T cell antigens recognized preferentially among individuals who are resistant to infection or who are infected and have mild or no clinical disease may provide new targets for the design of vaccines aimed at treating and/or preventing HSV-2 infection.

We identified two linear peptides on BRAF, P10 and P25, recognized preferentially by RA patients.

Interestingly, Sm29 is recognized preferentially by IgG1 and IgG3 from putatively resistant (PR) more than chronically infected (CI) individuals [ 11].

There is a significant difference observed in the 130 kDa and 160 kDa antigens, which are being recognized preferentially by antibodies of asymptomatic patients.

This demonstrates that optimal bortezomib-induced activation of MMP-1 transcription requires an AP-1 binding site recognized preferentially by a c-Jun/c-Fos heterodimer.

Similar(53)

Therefore, homoisocitrate dehydrogenase appeared to recognize preferentially an extended conformation of homoisocitrate.

RIG-I has been found to recognize preferentially 5'-triphosphate poly-U/A-rich single-stranded RNA and short double-stranded (ds) RNA [10], [11], [12], whereas MDA-5 recognizes long dsRNA [13].

The majority of integrins, the proteins mainly responsible for the adhesion of cells to ECM, recognize preferentially aspartatic acid- or glutamic acid-based sequences as ligands (e. g. most common, RGD-residues in fibronectin as well as rarer LDV-, RTD- and KQAGD-residues, but also YRGRD alone as artificial "minimal-peptide") [28], [29], [33] [36].

Epigenetic markers are conserved through bacterial generations thanks to the capacity of methyltransferases to recognize preferentially hemimethylated DNA.

Instead, CLKs appear to recognize preferentially the three Ser-Pro dipeptides in the RS domain, the phosphorylation of which has been proposed to change the conformation of the RS domain and regulate SRSF1 contact sites required in the spliceosome [ 27].

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