Exact(5)
The results of our study indicate that, for the majority of the compounds in PubChem, their structural similarity to other compounds can be recognized predominantly by either 2-D or 3-D neighborings, but not by both, showing a strong complementarity between 2-D and 3-D neighboring results.
Graphical Abstract The binned distribution of the neighbor preference indices (NPIs) for all compounds in PubChem (left) has a bimodal shape with two maxima at NPI = ±1 and a minimum at NPI = 0, indicating that structural similarity between compounds in PubChem can be recognized predominantly by either 2-D or 3-D neighborings, but not by both.
Strikingly, for the 35 % GalCer bilayers, the VLPs recognized predominantly the edges and not the center of the GalCer domains.
We also found that several exons are recognized predominantly as exons in one tissue and also as introns in another tissue.
For instance, when boiled sonicates were used as an antigen in immunoblot assays, IgM antibodies from infected WT mice recognized predominantly three bands (~50 kDa, ~42 kDa, and ~37 kDa) while only one band (~37 kDa band) of the three was recognized by the IgM antibodies of infected CD40L deficient mice.
Similar(55)
Structural studies of the interaction of antibiotics with the ribosome have revealed that these small molecules recognize predominantly the rRNA components.
Note that the Lc3 antibody in zebrafish recognizes predominantly the cleaved Lc3B-II form, which still accurately reflects autophagic activity41 (Supplementary Fig. S2A), and we were only able to detect a faint signal for Lc3B-I in zebrafish lysates (Fig. 1A).
One of the protein conjugates was used to elicit the formation of monoclonal antibodies, which were evaluated using the biotin conjugates in an enzyme-linked immunosorbent assay employing streptavidin-coupled alkaline phosphatase, and thus shown to recognize predominantly the indole-3-acetic acid moiety.
For the second year in a row, no actors of color were nominated for an Academy Award, echoing much of the Academy's 92 year history of recognizing predominantly white men.
While these assays are not identical, those recognizing predominantly the full-length intact molecule such as the one we employed are used extensively by researchers in the clinical field [ 16, 27, 37, 38].
Previous studies have shown that human autoantibodies against SRP immunoprecipitate the 7S RNA and all the SRP protein subunits from HeLa cell extracts, but recognize predominantly the SRP54 subunit on immunoblots [ 12- 14].
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