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Antibody fragments are being engineered to achieve rapid targeting and rapid blood clearance [ 16].
Furthermore, the electronic system was important to keep track of migrant children and indicate their migrating trend and it would allow rapid targeting of additional activities.
In addition, because of their rapid targeting and faster clearance compared to intact antibodies, divalent antibodies are widely used for tumor imaging [ 13, 23, 25].
As shown in Table 1, maximal tumor uptake of the I-Dmab scFv -Fc antI-Dmab scFv -Fcted at 1–3 h after I-Dmab scFv -Fccantibody rapid targeting of the Dmab(scFv)-Fc antibody.
To be developed as a tumor imaging agent, an antibody must have the following essential characteristics: low immunogenicity, high specificity and affinity for antigen, rapid targeting and clearance, and efficient production and purification [ 25, 28].
This results in one oxygen being incorporated into the prolyl residue of HIF- α, allowing rapid targeting and degradation by the proteasome pathway via the von Hippel Lindau (VHL) protein and the ubiquitin E3 ligase complex.
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The e-mail continued: "Thus far, it seems that no press or blogs have discovered it, but we will be keeping a close watch and may be calling on you if we need a rapid, targeted response.
In contrast to traditional methods of mutagenesis, injection of morpholino oligonucleotides permits much more rapid targeted gene knockdown.
However, this indicator-based system lacked an early warning component, and the information produced was untimely and insufficient for real-time monitoring and to direct a rapid, targeted response.
In addition, several new genomics technologies, such as 'targeting induced local lesions in genomes' (TILLING), zinc finger nuclease (ZFN) and transcription activator-like effector nuclease (TALEN), have been developed to perform more rapid targeted gene disruption in zebrafish and medaka (Huang et al., 2012).
The national system had been able to detect and confirm the outbreak etiology but required external support to monitor the spread of cholera and coordinate response, because much of the information produced was insufficiently timely for real-time monitoring and directing of a rapid, targeted response.
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