Corals also have an efficient DNA repair mechanism that rapidly targets UV-inflicted DNA damage when it occurs [18].
Fur4-GFP was rapidly targeted back up to the plasma membrane in vps37Δ cells after the addition of glucose but not upon addition of glucose+CHX.
These results could be interpreted to suggest that newly synthesized GluR2 is rapidly targeted to the cell surface and there is a corresponding increase in degradation of intracellular GluR2 to maintain balance.
Under normal oxygen tension, HIF1α is hydroxylated and rapidly targeted for proteasome-mediated degradation through the ECV (or VBC, namely elongin BC/Cul2/VHL) E3 ubiquitin ligase complex which requires the recognition of von Hippel Lindau (VHL) tumor suppressor [4] [6].
These transcriptional changes were initiated very early during (48 H) the course of the transcriptional response to immobilization, indicating that mitochondrial bioenergetic pathways are rapidly targeted for transcriptional down-regulation following immobilization.
Since we have also shown that TIEG1 and Runx2 proteins interact, one could speculate that complexes consisting of these two proteins could be rapidly targeted, together or separately, for proteasomal degradation.
Remarkably, studies carried out in HeLa and dendritic cells showed that 30% of newly synthesized proteins are aberrant and are rapidly targeted for degradation through the ubiquitin-proteasome pathway.
Consistent with a previous report [32], our data showed that CQ reduced the density of TSQ fluorescence and AMG staining in the mossy fibers, suggesting that intraperitoneal treatment of CQ rapidly targets chelatable zinc pools in the hippocampus of the gerbil brain [32].
With this pretargeting method, tumours are specifically and rapidly targeted.
