prohibitive toxicity

USAGE SUMMARY

The phrase "prohibitive toxicity" is correct and usable in written English.
It can be used in contexts discussing substances or compounds that are harmful or dangerous to health, often in scientific or regulatory discussions. Example: "The research indicated that the chemical had prohibitive toxicity, making it unsuitable for use in consumer products."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

12 human-written examples

Over the years, copper (Cu II)) has gain the attention of chemists due to its prohibitive toxicity and nonbiodegradable nature.

Nanoscale Research Letters

Chemotherapy was stopped in cases of disease progression or prohibitive toxicity.

BMC Cancer

Cycles were repeated in the absence of progressive disease or prohibitive toxicity.

British Journal of Cancer

In the absence of disease progression or prohibitive toxicity, patients received a maximum of six doses.

British Journal of Cancer

Cycles were repeated if no progressive disease or prohibitive toxicity occurred.

British Journal of Cancer

Patients with partial response (PR) continued with the protocol treatment until PD or prohibitive toxicity developed.

British Journal of Cancer

Human-verified similar examples from authoritative sources

Similar Expressions

47 human-written examples

The addition of ASA404 to carboplatin and paclitaxel was generally well tolerated and did not produce prohibitive additional toxicity.

British Journal of Cancer

Because of prohibitive dermatological toxicity and disappointing preliminary efficacy, this combination of paclitaxel/cetuximab was not considered promising.

Breast Cancer Research

They were each receiving cycloserine at 500 mg daily and while escalation of dose to 750 mg daily is possible (split in two doses in morning and before bed), such increase may have prohibitive neuropsychiatric toxicity.

BMC Infectious Diseases

Most drugs for these diseases were developed in the last century, and they are unsuitable because of insufficient efficacy, toxicity, prohibitive cost, and/or increasing drug resistance.

Chemical Reviews

Of course, this might result in greater toxicity and prohibitive costs, but it would be an option worth considering.

Antimicrobial Agents and Chemotherapy

Expert writing Tips

Best practice

When discussing clinical trials or treatment protocols, use "prohibitive toxicity" to clearly indicate a level of adverse effects that necessitates discontinuation or dose adjustment.

Common error

Avoid using "prohibitive toxicity" when simply describing common side effects. This phrase should be reserved for instances where the toxicity is so severe it prevents further treatment.

Linguistic Context

The phrase "prohibitive toxicity" functions as a noun phrase where the adjective "prohibitive" modifies the noun "toxicity". As Ludwig AI suggests, this construction describes a level of toxicity that is so high it prevents a certain action or outcome.

Expression frequency: Uncommon

Frequent in

Science

90%

News & Media

7%

Formal & Business

3%

Less common in

Academia

0%

Encyclopedias

0%

Wiki

0%

Ludwig's WRAP-UP

In summary, "prohibitive toxicity" is a phrase used to describe a level of toxicity that is unacceptable and prevents a certain action or outcome. According to Ludwig AI, it is grammatically correct and is frequently found in scientific and medical contexts. The phrase indicates that the level of adverse effects is so severe that it necessitates discontinuation or dose adjustment. When using this phrase, it is important to distinguish between common side effects and toxicity levels that limit or prevent further treatment. Ludwig's examples show the phrase used across scientific articles and news publications, suggesting a relatively uncommon but well-established usage in formal and scientific discourse.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

Unacceptable toxicity

Replaces "prohibitive" with "unacceptable", focusing on the unsuitability of the toxicity level.

Intolerable toxicity

Substitutes "prohibitive" with "intolerable", emphasizing the inability to withstand the toxic effects.

Excessive toxicity

Replaces "prohibitive" with "excessive", highlighting the overabundance of toxic effects.

Severe toxicity

Replaces "prohibitive" with "severe", focusing on the intensity and seriousness of the toxicity.

Dangerous toxicity

Substitutes "prohibitive" with "dangerous", emphasizing the potential harm from the toxicity.

Unmanageable toxicity

Replaces "prohibitive" with "unmanageable", highlighting the difficulty in controlling the toxicity.

Life-threatening toxicity

Focuses on the potential for the toxicity to cause death.

Debilitating toxicity

Emphasizes the weakening or disabling effects of the toxicity.

Unsupportable toxicity

Highlights the inability to medically support a patient experiencing that level of toxicity.

Treatment-limiting toxicity

Indicates that the toxicity prevents further treatment or intervention.

FAQs

How is "prohibitive toxicity" generally assessed in clinical trials?

Assessment often involves monitoring adverse events using standardized scales (e.g., CTCAE criteria) to determine if the severity reaches a level that warrants stopping the treatment. Factors like reversibility and impact on quality of life are also considered.

What factors might influence whether a toxicity is considered "prohibitive"?

Patient's overall health, availability of alternative treatments, and the specific goals of therapy all play a role. A toxicity deemed prohibitive in one situation might be acceptable in another where the potential benefits are greater or no alternatives exist.

What can I say instead of "prohibitive toxicity"?

You can use alternatives like "unacceptable toxicity", "intolerable toxicity", or "excessive toxicity" depending on the context.

Is "prohibitive toxicity" only used in the context of medical treatments?

While commonly used in medicine, it can also apply to environmental or chemical exposures, indicating a level of toxicity that prevents safe use or requires significant mitigation measures. It suggests a toxicity level that effectively forbids the continuation of an activity or the use of a substance.