intolerable toxicity

USAGE SUMMARY

"intolerable toxicity" is correct and usable in written English and means that the toxicity is extreme or severe or something that cannot be tolerated.
For example, "The pollutants in the water have caused an intolerable toxicity in the surrounding area."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

60 human-written examples

Treatment continued until progressive disease or intolerable toxicity.

Lung Cancer

No intolerable toxicity was observed during this process.

Journal of Cellular Immunotherapy

Successful chemotherapy of cancer depends on the delivery of sufficient concentrations of an effective drug to tumor cells without causing intolerable toxicity to the patient.

International Nano Letters

Drug resistance enforces high dose administration of antibiotics, often generating intolerable toxicity, development of new antibiotics, and requests for significant economic, labor, and time investments.

Journal of Controlled Release

Cetuximab (400 mg/m2 on day 1 with subsequent doses of 250 mg/m2 weekly) was administered until progression or intolerable toxicity up to a maximum treatment duration of 12 months.

Lung Cancer

Recent results from a multicenter, randomized phase III trial, the UK ABC-02 trial that evaluated GEM with or without cisplatin in patients with advanced or metastatic BTC have demonstrated a clear survival advantage (hazard ratio 0.68, P = 0.002) for the combination of GEM and cisplatin (GC regimen) without added clinically intolerable toxicity [5].

Surgical Case Reports

Patients were treated until disease progression or intolerable toxicity.

British Journal of Cancer

Treatment was continued until disease progression or intolerable toxicity.

British Journal of Cancer

Treatment was administered until disease progression or intolerable toxicity.

British Journal of Cancer

Doses were given daily until disease progression or withdrawal due to intolerable toxicity.

British Journal of Cancer

No patient in this study withdrew from CRT because of any intolerable toxicity.

BioMed Research International

Expert writing Tips

Best practice

When discussing medical treatments, clearly define what constitutes "intolerable toxicity" in your context. This ensures clarity and avoids ambiguity in research and clinical settings.

Common error

While "intolerable toxicity" implies a subjective limit, avoid using it in contexts where objective measures of toxicity are available. Prioritize quantifiable data whenever possible.

Linguistic Context

The phrase "intolerable toxicity" functions primarily as a noun phrase, often used as the object of a preposition or as part of a larger noun phrase within medical and scientific contexts. It signifies a level of toxicity that is unacceptable or unsustainable for a patient or system, as confirmed by Ludwig.

Expression frequency: Very common

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Academia

0%

Ludwig's WRAP-UP

In summary, "intolerable toxicity" is a noun phrase used to describe a level of toxicity that is unacceptable, most frequently found in scientific and medical contexts. According to Ludwig, it's grammatically correct and serves the purpose of indicating a threshold beyond which a treatment or exposure cannot be sustained. While the phrase itself is straightforward, its application requires careful definition and objective assessment, especially within clinical and research settings. Alternatives such as "unacceptable level of toxicity" or "severe adverse effects" may be used depending on the context.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

unacceptable level of toxicity

This alternative focuses on the acceptability of the toxicity level.

extreme toxicity

This alternative highlights the intensity of the toxic effects.

clinically significant toxicity

This alternative emphasizes the clinical relevance of the toxicity.

severe adverse effects

This alternative uses broader terms to describe the negative consequences.

toxicity requiring cessation of treatment

This alternative is more descriptive and explains the consequence of the toxicity.

insufferable toxic reaction

This alternative emphasizes the patient's experience of the toxicity.

debilitating toxicity

This alternative stresses the weakening effect of the toxicity.

life-threatening toxicity

This alternative highlights the potential severity and danger.

unbearable side effects

This alternative focuses on the tolerability of side effects.

harmful level of poison

This alternative replaces toxicity with 'poison', highlighting its harmful nature.

FAQs

How is "intolerable toxicity" determined in clinical trials?

In clinical trials, "intolerable toxicity" is typically defined by specific criteria outlined in the study protocol, often using grading scales like the Common Terminology Criteria for Adverse Events (CTCAE). These criteria help standardize the assessment and reporting of adverse events, including the point at which toxicity becomes intolerable, leading to treatment modification or discontinuation.

What factors influence a patient's experience of "intolerable toxicity"?

A patient's experience of "intolerable toxicity" can be influenced by various factors, including their overall health, age, pre-existing conditions, concurrent medications, and individual pain tolerance. Psychological factors like anxiety and expectations can also play a role. Thus, the determination of intolerability is often a complex assessment.

What are some alternatives to using the phrase "intolerable toxicity"?

You can use alternatives like "unacceptable level of toxicity", "severe adverse effects", or "extreme toxicity" depending on the specific context.

When should treatment be stopped due to "intolerable toxicity"?

Treatment should be stopped when the severity of the toxicity outweighs the potential benefits of continuing the treatment. This decision is usually made by a healthcare professional, taking into account the specific toxicity, its impact on the patient's quality of life, and available alternative treatments.