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They increase to a maximum and decline slowly, disappearing as early production difficulties are overcome and the product settles into a market niche.
Even if nonrecombinant uricase from Aspergillus flavus was developed and used for reducing hyperuricemia in human tumour lysis syndrome in the late 1960s [ 82, 83], its use was complicated by production difficulties, the short half-life of the product, and the high frequency of severe allergic reactions (5%) [ 83].
Continuous production difficulties had already plagued the Dreamliner.
"Production difficulties got in the way," she said.
Like most movies of its size, "Oz" had production difficulties.
There were major production difficulties, with rumours that Francis would be fired or Marlon would be.
Brad Pitt has a great deal riding on "World War Z," a $190 million zombie thriller that encountered production difficulties.
This sober internal analysis differs from optimistic public statements by Shell that continued even after news of production difficulties began to circulate outside the company.
Kidding aside, said Gordon-Levitt, suggestions that the movie's production difficulties had anything to do with government surveillance miss the point.
Sanofi Pasteur, the largest supplier, has delivered only 30 million of its projected 50.5 million doses so far, in part because of production difficulties, a spokeswoman said.
But he cautioned that Iran had run into production difficulties, and he said, "It's going slow — slower than they anticipated, but they are moving in that direction".
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