Exact(1)
We have engineered and validated a set of expression platforms that regulate transcription through a secondary structural switch that can host a variety of different aptamers, including those derived through in vitro selection methods, to create novel chimeric riboswitches.
Similar(7)
A riboswitch consists of two parts: an aptamer that binds a small molecule and an expression platform that regulates gene expression.
The inflammasome is a molecular platform that regulates the activation of caspase-1, which leads to the cleavage of interleukin-1 β (IL-1 β).
These complexes would provide a cytoskeletal platform that regulates the accurate clustering and activation of β2-integrins [4], facilitating their function [34].
14-3-3ζ is a member of a highly conserved family of 14-3-3 14-3-3 14-3-3 it functions as a scaffold or proteins thandregulates the actitity and stability ofunctionsting proteins by binding to their phosphoserine asd phosphothreonine motifs [ 11- 15].
Growing microtubule ends serve as transient binding platforms for essential proteins that regulate microtubule dynamics and their interactions with cellular substructures.
This technology, combined with single cell analysis methods, provides a platform for exploring the mechanisms that regulate cell behaviour.
Riboswitches that regulate translation have expression platforms that fold to either occlude or expose the RBS, and can be either activators such as the S-adenosylhomocysteine (SAH) riboswitch ahcY [ 63] (Fig. 2A), or repressors as in the case of the adenosylcobalam [ 64] and thiamine [ 65] riboswitches (Fig. 2A).
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