Kinetic studies confirmed that the physiological substrate was acetone.
A physiological substrate of mammalian Autophagins is the protein LC3.
Thus, FTO's true, physiological substrate(s) and function remains unclear.
Thus, CD44 and CD81 likely represent physiological substrate of MARCH-I and VIII.
Previous studies have identified CRMP4 as a physiological substrate of GSK3 [32], [32].
This finding raises the possibility that the physiological substrate for YOR283w could be a PI phosphate.
Moreover, it has been suggested that GRP94 is a physiological substrate for calpain [23].
Fundamental to addressing these questions is the identification of LRRK2's physiological substrate(s).
Since DDX3 is also a helicase (see also below), dsRNA or DNA is also a physiological substrate.
B. recurrentis binds PLG and upon processing to enzymatically active plasmin by human uPA the surface bound protease is shown to degrade the physiological substrate fibrinogen.
Evidence that YY1 is a physiological substrate for Plk1 is strengthened by the physical interaction between YY1 and Plk1 shown by co-immunoprecipitation.
