Four other regulators (AcuR1-4: OF6589, 6586, 6589, 6586) belong to the LuxR family and might participate in control and fine tuning of the aculeximycin production [ 48].
Thus, REP2 sequences participate in control of expression of genes essential for the interaction of N. meningitidis with human host cells (Morelle et al. 2003).
Finally, in the MM group, genes in the top 10percentt of high H4K5Ac binding belong to genes that participate in control of gene expression (188 genes), cellular function and maintenance (209 genes), and cell morphology (207).
Down-regulation of RARα or RARβ altered the cellular morphology from a more cobblestone-like structure to that of a more spindle-like shape, suggesting that both isotypes could participate in control of epithelial to mesenchymal transition (EMT).
This rapid clearance suggests involvement of the innate immune system, but the infectivity of Δp66 bacteria was not rescued in mice deficient in either TLR2 or MyD88, signalling molecules known to participate in control of B. burgdorferi infection (Ristow et al., 2012).
