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With this high dose, death was not observed in ICR mice, but mild diarrhea was the only observed side effect.
Thrombocytopenia, which is a constantly observed side effect of these drugs, is limiting dose escalade and drug combinations.
The most frequently observed side effect was hypotension which generally occurred during inhalation anesthesia.
Most commonly observed side effect were constipation (observed 86%), nausea (33%), drowsiness (30%), and delirium (9%).
Skin toxicity in the form of an acneiform folliculitis usually affecting the face (65% of those affected) and trunk (42% of those affected) was the most frequently observed side effect.
Similar(55)
According to FDA prescribing information concerning the observed side effects of AVA (BioThrax), local adverse reactions have been observed (especially at injection site), for example, tenderness, pain, erythema, edema, and arm motion limitation; (≥5%) as well as systemic adverse reactions: fatigue headache and muscle aches [ 99].
The observed side effects were dizziness, drowsiness and increase in appetite.
We wanted to assess the risk factors for overdosing in ICU and the related observed side effects.
Considering the observed side effects, doses should be accurately monitored and reduced, particularly when renal replacement therapy is needed.
These results suggest that Fe3O4Au x Ag y NPs can be considered as an alternative agent to overcome the observed side effects in tumor treatment.
Finally, before 2012, the reason for assessing oxa- or cloxacillin concentration was not mentioned; we could suppose clinicians suspected an overdosing because of observed side effects.
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