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Focus is drawn on details like normalization issues, robustness, and representativeness.
The up-regulation of background genes may be due to the secondary effects of miRNA mis-expression or normalization issues.
The small (high number) scaffolds contain significantly fewer genes and distributing these scaffolds evenly over the 5-array set may prevent signal normalization issues.
We exclusively focused on Affymetrix® genomic datasets to avoid cross-platform normalization issues.
The Pearson correlation reflects all these noise sources, while remaining insensitive to normalization issues.
Affymetrix® genomics datasets were exclusively used to avoid cross-platform normalization issues.
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The methodology adopted allows a large range of variation of the neighborhood, reflecting the local citation network, and partly alleviates the "cross-scale" normalization issue.
This is not in itself a normalization issue, but it may be advantageous to minimize the differences so that the ranking of potential differentially methylated loci is more accurate [ 5].
This innovative data analysis tool allowed us to circumvent the normalization issue and given the high reproducibility of this procedure, we believe that it could be routinely used for the analysis of miRNAs also in cancer clinical series.
A LETTER FROM VIETNAM about normalization and POW/MIA issues.
The New Yorker, May 24 , 1993P. 43 A LETTER FROM VIETNAM about normalization and POW/MIA issues.
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