Sentence examples for mutations that ultimately from inspiring English sources

By iteratively screening libraries of a caffeine demethylase, we identified beneficial mutations that ultimately increased the enzyme activity in vivo by 33 fold and the product selectivity by 22 fold.

The prevailing theory for the molecular basis of evolution involves genetic mutations that ultimately generate the heritable phenotypic variation on which natural selection acts.

Resistance to these drugs is the result of various somatic mutations that ultimately trigger aberrant phosphoinositide 3-kinase (PI3K /Akt activation [ 41].

By analogy with bacterial models of antibiotic resistance, such an intermediate state may be unstable, but enable treated cells to survive in the presence of drug long enough to acquire mutations that ultimately confer sustained drug resistance (Balaban et al., 2004).

The authors suggested that the acquisition of the genetic translocations had occurred at the stem cell stage, as these cells were able to differentiate into B cells and cells from the myeloid lineage, and some of which acquired additional mutations that ultimately resulted in AML [ 72].

The decelerating effect of this interference on the mutation that ultimately prevails can be quite pronounced, because those other clones that reach high frequency tend to be strong competitors.

When cells are constantly dividing, they are at greater risk from secondary transforming events (mutations) that will ultimately lead to the development of cancer.

It is these errors in replication, or mutations, that are ultimately responsible for all of the variation that the other three forces of evolution act upon.

Thus, it is likely that trade-offs resulting from pleiotropy bias the mutations that are ultimately fixed by selection during evolution (Stern and Orgogozo 2009).

However, increased proliferative capacity and evasion of apoptosis induced by E6 and E7 can lead to the accumulation of DNA damage and mutations that can ultimately result in malignant transformation and carcinogenesis.

MuTect and SomaticSniper had comparable sensitivity in our dataset, as they both found approximately the same proportion of the 229 TP mutations that were ultimately confirmed, while the sensitivity of JointSNVMix2 was 10% lower (Table  3).