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Because we found many mutations that potentially affect metabolism and growth in PAO6609, we used defined siderophore deletion mutants of the siderophores pyoverdine and pyochelin for these experiments.
Furthermore, the lack of paired samples within our cohort reduces our ability to identify or directly infer specific genetic mutations that potentially drive metastasis or disease progression.
A recently published database, SomamiR, lists 26 somatic mutations that potentially affect the functioning of microRNAs in various diseases (Bhattacharya et al. 2013).
Using next-generation DNA sequencing and RNA sequencing of tumours from paired tumour and TIL samples, many mutations that potentially carried a new T-cell epitope were found.
We obtained a full view of the exome signature of SAM strains and report herein several mutations that potentially cause various pathogenic phenotypes.
One strength of the sec5 ts system is that it allows for unbiased screens using genetic mosaics to find recessive mutations that potentially block compensatory growth.
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The biochemical analysis of mtDNA mutations requires that viable cells are obtained from patients with such mutations and that potentially confounding nuclear events are controlled.
She whittled this list to 54 rare mutations that could potentially shut down the gene in which they were located.
In simple terms, the study aims to understand and analyze: a) rules that aid interactions between DNA and certain biomolecules known as transcription factors (that "activate" a gene); and b) rules (mutations) that could potentially damage such interactions.
We have presented evidence that the bi-directional SIFT algorithm is capable of finding a subset of mutations that are potentially functionally activating.
Thus, the best option to identify HA mutations that may potentially give rise to NAI resistance may be to perform sequence analysis of the HA gene to specifically look for mutations at or near sialic acid binding site [9].
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