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The frequency of derived mutations tends to be greater in breakpoint than in nonbreakpoint regions, and older arrangements have accumulated larger numbers of fixed derived mutations.
Removing carboxylate groups from side chains dramatically reduces or eliminates the ability of both channels to bind calcium, while preserving carboxylate groups with charge-conserving mutations tends to partially rescue calcium sensitivity.
Resistance acquired from chromosomal mutations tends to be costlier than resistance conferred by plasmids, while plasmids conferring resistance to a wider range of antibiotics tend to be more costly than those with a narrow range.
42 Furthermore, combinations that do or do not significantly coexist have been found for each gene mutation, suggesting that the type of founding mutations tends to prescribe the type of subclone mutations.
As the frequency of frameshift mutations tends to increase as the HT length increases [ 19, 20], longer HTs located closer to the beginning of genes are likely to allow for more efficient phase variation and gene inactivation as compared to shorter HTs.
Similar(55)
These structurally conserved mutations tend to cluster into specific mutational hotspots which may be shared by multiple kinase genes.
Both mutations tend to be proximal tumor location and mucinous histology, but KRAS-mutated tumors are more common in female patients.
Mutations tend to take place at a fairly constant rate over history.
Like behavioral and physical characteristics, those canine diseases and the responsible mutations tend to segregate according to breed, with many prone to more than one affliction.
The HA mutations tend to map to regions associated with receptor binding of the HA.
In contrast, secondary mutations tend to occur away from the nucleotide-binding pocket.
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