Sentence examples for mutations contributes to from inspiring English sources

Moreover, endothelin-1 upregulated by BMPR2 mutations contributes to PH pathogenesis (Star et al., 2013).

The analysis of the coding sequence and expression pattern of p53 and p21 suggests that loss-of-heterozygosity of Trp53 caused by somatic mutations contributes to accelerated mammary tumorigenesis in this model.

Cyclin D Cdk4/6 activity combined with other signal transduction pathway mutations contributes to increased cellular metabolism that we speculate is monitored by an unknown metabolic sensor.

We suggest that the selection for TP53 mutations contributes to the poor outcome observed in tumours with high EZH2, but not BMI1, expression.

Our results show that the gain of function conferred by PIK3CA mutations contributes to resistance to HER2 inhibitors by partially uncoupling PI3K signaling from HER2 inhibition.

One major question is whether the accumulation of mtDNA mutations contributes to PD pathogenesis by the gradual replacement of wild-type DNA, failure to synthesize mitochondrial proteins, causing respiratory chain deficiency, neuronal dysfunction and ultimately, neuronal death.

In human, NaV channels are therapeutic targets as their mutations contribute to many diseases.

Oncogenic IDH1 and IDH2 mutations contribute to cancer via production of R-2-hydroxyglutarate (2-HG).

In cancer patients, tumor gene mutations contribute to drug resistance and treatment failure.

These two mutations contribute to the aberrant PML-RARA SUMOylation and NB formation (Goto et al., 2011).

The price of such rich diversity may be that mutations contributing to mental disorders such as schizophrenia sometimes emerge.