Sentence examples for mutations on expression from inspiring English sources

Suppression of TPE was monitored in the strain y1 w118; P[w+] 39C-5, (39C-5) [57] by monitoring the effect of the various mutations on expression of the mini-white gene from the reporter construct inserted into the 2L telomere.

To analyze the effect of individual mutations on expression of HXT4 and SUC2 in EvoClone2, we made seven strains, each with a different allelic combination of the five causal mutations.

To determine if more than one nst gene is required for telomeric silencing, we combined nst mutations described above with this hph marker and then tested the effect of the mutations on expression of hph at Tel VR.

The effect of cysteine residue mutations on expression and thermostability was related to the position of the residue(s) and whether it led to aberrant disulfide bond formation, improper folding, and sometimes proteolysis [ 41].

49 In this study, the investigators demonstrated that an esco2 mutation (R80S) actually suppresses expression of notch1a (a neural development marker) and its downstream genes, as well as notch3 (a vascular differentiation marker), suggesting an important effect of esco2 mutations on expression of developmental genes in Roberts syndrome.

To investigate the effect of the identified MUSK mutations on expression and function of MuSK we engineered the identified MUSK mutants using site-directed mutagenesis of human and mouse full-length MuSK cDNA constructs and expressed them in human heterologous cells and mouse C2C12 and MuSK−/− myotubes.

Other reports have suggested that the impact of the tcaR mutation on expression of sarS also has a profound impact on S. aureus regulatory circuits [22], [50].

However, these findings contrast with a recent report of the phenotypic effect of ciaRH mutation on expression of htrA in transparent and opaque variants [58].

Assuming that the impact of the mutation on expression can be detected, experimental validation of IT-based mutation analysis can reveal its limitations.

The Ku proteins play a role in telomere function in other organisms [ 41] so we tested the effect of the mus-52 mutation on expression of the Tel VIIL-targeted bar marker.

Of particular interest was their observation that mutation location contributes to cognitive disability but not to motor disability, consistent with the view that that tissue specific effects are mediated at least in part by the effects of DMD mutations on the expression of tissue specific isoform expression.