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These male and virgin female progeny were test crossed in single pair matings to individuals from a marker stock homozygous for the or and pr mutations on an AR background (Figure 2).

In this work, we report a valuable genomics-based protocol for the structural analysis of deletion mutations on an heterozygous background.

The direct sequencing was performed to analyze PIK3CA mutations on an ABI PRISM 3700 DNA Analyzer (Applied Biosystems) at the sequencing core of Beijing Genomics Institute (BGI, Beijing).

Because many genes are infrequently mutated and large disease-specific datasets are often not available, other approaches may be more suitable for identification of functional mutations on an individual gene basis.

The fitness is determined by the number of deleterious mutations on an individual's genome and the chosen mutation interaction for the simulation (independent interaction, quadratic interaction or truncation interaction).

Hence, observed mutations on an unglycosylated mutant from E. coli might not be transferable to a glycosylated enzyme from a plant or yeast host (Hiner et al. 1995) and may require additional experimental data.

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We found four EGFR gene mutations (one on a fine needle aspirate and three on bronchial washings).

Random mutations thus accumulate in HSCs during repeated replications unless the mutations bring on a loss of stem cell function.

The arctic groups had the most mutations on a gene called ATP6.

Here, we have presented a computational method for designing dimeric thermostable protein based on rational mutations on a mesophilic protein.

They discovered that those with the disorder had mutations on a specific gene, called GPR54, which is known to produce a receptor in cell membranes.

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