Exact(6)
Based on TEM experimental observations, a model describing the reorientation of the twinned variants on an atomic scale was developed to explain the reversible motion of the boundary.
We screened DNA sequence variants on an exome-focused genotyping array in >300,000 participants with replication in >280,000 participants and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and/or triglycerides (TG).
While ongoing clinical trials will determine if routine use of pharmacogenetic testing may be beneficial, the data today support pharmacogenetic testing for certain variants on an individualized, case-by-case basis.
This allows for collapsing variants only when needed due to their rarity, and analyzing more common variants on an individual basis.
PTEN point mutations were identified by denaturing gradient gel electrophoresis (DGGE) screening followed by sequencing of the variants on an ABI DNA sequencing machine [ 11].
This nomenclature system allows flexibility and agnosticism with regard to phylogeny of variants through the long-established use of paralog number suffixes to indicate individual unique variants on an organism-specific basis without implying phylogenetic relationships.
Similar(54)
The simplest variant detection methods identify variants on a per-sample basis, one position at a time.
Meatballs, meatloaves, burgers, koftas – they're all just variants on a theme, and have been gracing tables for centuries.
But they are all variants on a theme — a theme that has been alive and well for some time.
Fowler, D.M., Stephany, J.J. & Fields, S. Measuring the activity of protein variants on a large scale using deep mutational scanning.
For illustration, we directly compare the performance and robustness of several variants on a benchmark problem.
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