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Exact(4)
The final catalog of mutations is determined by the strength and duration of exposure to each mutational process.
The detection and extent of somatic mutations is determined informatically using computational programs for variant calling.
The frequency of inherited mutations is determined by a process of multigenic mutation-selection balance (Nunney 2003), a population-level phenomenon not controlled by individual genotypes; however, somatic mutation is controlled at the individual level.
This finding is highly unexpected under the classical neutral theory of molecular evolution, which argues that the fixation probability of nonsynonymous mutations is determined by (and serves as an estimator for) selective pressure, and as such, should be independent of neutral mutation rate [ 3- 5].
Similar(56)
By analyzing the targeting site on the genome of corresponding transgenic plants, the mutations were determined.
During three generations of replication, possible mutations are determined by the outcome of roulette spins.
The crystal structures of M. jannaschii tyrosyl-tRNA synthetase and its mutations were determined, which provided an opportunity to design aminoacyl-tRNA synthetases specific for other unnatural amino acids.
The identity of the mutations was determined by sequencing.
Gag mutations were determined in relation to the estimated time of seroconversion.
The purified clonal fragments were then sequenced (20 50 clones per sample) and linkage between integrase mutations was determined.
The prevalence and profile of drug-resistant mutations were determined using Sanger sequencing and ultra-deep pyrosequencing.
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