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Exact(7)
Slower clearance of deleterious mutations increases the accumulation over time of genetic variability.
While allowing single back mutations increases the number of accessible pathways by 50% (to 27), path repeatability is only mild affected, decreasing to 7.1%.
However, the amplification of deleterious mutations increases the risk of host lineage extinction [ 40, 55].
The presence of germline BRCA1 mutations increases the risk of developing breast cancer and ovarian cancer in young women [ 55].
Further studies are necessary to determine whether the truncation of envelope proteins by drug-resistant mutations increases the HCC risk as well.
Including SNMs in double and complex mutations increases the genome-wide mutation rate estimate to 2.34 ± 0.23 × 10−10 per base per generation.
Similar(53)
α is the multiplicative factor by which a mutator mutation increases the somatic mutation rate per cell generation, e.g. the magnitude of the genetic instability.
In all groups, the mutations increase the risk of certain other cancers as well.
The sperm of older men contains a greater number of mutations, increasing the genetic disorders.
But because so many marry relatives — some 65percentt of Bedouin in Israel's Negev marry first or second cousins — they have a significantly higher chance of marrying someone who carries the same mutations, increasing the odds they will have children with genetic diseases, researchers say.
It is anticipated that these mutations increased the local interactions that finally improved the thermostability and optimum temperature of luciferase.
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