Sentence examples for mutations raises the from inspiring English sources

The absence of mutations raises the critical question of how Notch signaling could be activated and pathological in breast cancer.

Including the 123 SNMS that we observed in double and complex mutations raises the genome-wide mutation rate estimate to 2.34 ± 0.23 × 10−10 per base per generation, which is not significantly different from the Farlow et al. (2015) estimate.

However, the finding that the K- ras 4A/4B ratio is also reduced in CRC cell lines that lack K- ras activating mutations raises the possibility that a regulated switch in alternative splicing of the K- ras proto-oncogene may also have a causal role in tumour progression [ 12].

The highest frequency of p53 mutations raises the possibility that p53 mutagenesis is a predominant factor for breast cancer development in this low-risk Japanese group, whereas in other cohorts different mechanisms are likely to account for the higher proportion of breast cancer.

Her heart problems could not be linked to any of the known mutations, raising the possibility that this SCN5A variation might somehow contribute to the irregularity.

If nonsynonymous mutations raise the fitness, their rate will be increased by positive selection (d N >d S ).

These mutations raise the possibility that additional drugs that target CML cells through alternative mechanisms to Bcr-Abl have the potential to be successful in treating imatinib-resistant CML patients (Druker et al, 2001).

Myriad executives have said that when a European laboratory finds a mutation in either of the two genes, 20 to 40 percent of the time it does not know if the mutation raises the cancer risk.

The mutation raises the net charge of the 100-residue N-terminal domain from +4 to +6.

It is likely that the Y254V mutation raises the free energy barrier of the transition state by disrupting coordination along the pathway of the translocation step.

The frequency of this mutation raises the possibility that variants with this alteration could be involved in the development of high grade intraepithelial and invasive disease.