Sentence examples for mutations including those from inspiring English sources

The most expedient approach would be to test PLX4032 in combination with other experimental drugs that targeted other mutations, including those seen in Dr. Flaherty's relapsing patients.

It is also becoming clear that somatic mutations, including those in known oncogenic drivers, are common in tissues starting at a young age.

Taken together, these findings suggest that BRCA2 mutations increase susceptibility to breast cancer by disrupting DNA repair and allowing cells to accumulate mutations, including those that foster cancer development.

Consequently, point mutations, including those associated with drug resistance, are spontaneously generated many times every day even in patients who never have received ART [5].

It is possible that other TAM mutations (including those not tested here, as well as those that are as yet undiscovered) in the reverse transcriptase could enhance Pi-dependent primer rescue, and thus have important consequences in vivo.

Indeed, we show here that C-terminal mutations, including those that disrupt helix-3 of the FABD, can restore the NLS function even under conditions when the BCR63-ABL kinase is active and autophosphorylated.

Additional hotspot mutations include those targeting KRAS (G12V/D), splicing factor SF3B1 (K700E, K700E), and c-Myc transcriptional repressor CTCF (R283C, H284P/Y/N).

These mutations include those in the SEMA domain and the juxtamembrane domain and an activating mutation in the tyrosine kinase domain [ 29].

Here we demonstrate that our collection of Top2 mutations includes those that produce no protein and those that produce near wild-type levels of a functionally compromised protein.

Examples of such "on" mutations are those substitutions that mimic activation loop phosphorylations, whereas examples of "off" mutations include those that alter catalytically essential residues of kinases, or residues in SH2 domains that are critical for phospho-tyrosine binding.

Previously reported human AMELX mutations include those resulting in a total loss of secreted protein (e.g. nonsense mutation in the signal peptide); mutations causing loss of the amelogenin C-terminal, and mutations affecting the amelogenin N-terminal region that includes a lectin-like, tri-tyrosyl domain reported to bind to N-acetyl d-glucosamine (14).