Sentence examples for mutations include those from inspiring English sources

These mutations include those in PHYTOCHROME D (PHYD), for which a small deletion was previously reported to alter the light sensitivity of a single accession42 and for which we identified multiple loss-of-function alleles.

These mutations include those in the SEMA domain and the juxtamembrane domain and an activating mutation in the tyrosine kinase domain [ 29].

Additional hotspot mutations include those targeting KRAS (G12V/D), splicing factor SF3B1 (K700E, K700E), and c-Myc transcriptional repressor CTCF (R283C, H284P/Y/N).

Examples of such "on" mutations are those substitutions that mimic activation loop phosphorylations, whereas examples of "off" mutations include those that alter catalytically essential residues of kinases, or residues in SH2 domains that are critical for phospho-tyrosine binding.

Previously reported human AMELX mutations include those resulting in a total loss of secreted protein (e.g. nonsense mutation in the signal peptide); mutations causing loss of the amelogenin C-terminal, and mutations affecting the amelogenin N-terminal region that includes a lectin-like, tri-tyrosyl domain reported to bind to N-acetyl d-glucosamine (14).

Point mutations, including those that introduce stop codons, were generated using Quickchange lightning (Agilent technologies).

It is also becoming clear that somatic mutations, including those in known oncogenic drivers, are common in tissues starting at a young age.

The most expedient approach would be to test PLX4032 in combination with other experimental drugs that targeted other mutations, including those seen in Dr. Flaherty's relapsing patients.

We developed a deep learning-based framework, ExPecto, that can accurately predict, ab initio from a DNA sequence, the tissue-specific transcriptional effects of mutations, including those that are rare or that have not been observed.

Taken together, these findings suggest that BRCA2 mutations increase susceptibility to breast cancer by disrupting DNA repair and allowing cells to accumulate mutations, including those that foster cancer development.

Consequently, point mutations, including those associated with drug resistance, are spontaneously generated many times every day even in patients who never have received ART [5].