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Interestingly, unlike germline mutations identified in CFC syndrome, no somatic mutations have ever been identified in MEK1/2 in any cancer type.
Note that this matches the heterozygous state of humans with FOXP2 mutations; no humans carrying homozygous mutations have ever been identified.
However, during 30 years of intensive molecular analysis of the 330 kb of the BX-C, only two such mutations have ever been identified; the Superabdominal (Sab) mutation in the IAB5 enhancer (Celniker et al. 1990) and the Hyperabdominal (Hab) mutation in the IAB2 enhancer (Lewis 1978).
This is reflected in the close spacing of repressor (KR and HB) and activator (FTZ) binding sites in enhancers that are known to recruit these factors in vivo and offers insight into why so few gain-of-function mutations have ever been discovered in the complex.
In contrast, the relative abundance of KR sites at the other embryonic enhancers from the BX-C may provide an explanation for the fact that no gain-of-function mutations have ever been characterized in the complex outside of IAB5 and IAB2.
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Many cancers have elevated Wnt signaling, but so far, no mutations in the CRD of any LEF/TCF have been reported and no mutations in Groucho/TLE or HDACs have ever been described.
Among the five patients with TP53 mutations who had ever obtained a CR and had available samples for study, three lost the original mutation at remission status, but two (patients 11 and 32) retained it (Table 5).
The mutation carriers were just as likely to have ever breast fed as the other two groups, and a very short duration of breast feeding each child was as common among the mutation carriers as among the controls.
I have ever tried".
have ever been collected.
"It's the highest mutation rate we've ever seen," he said.
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