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They caution that most of the drugs needed to target the colon cancer mutations have yet to be developed, but they say they are building the road map that they hope will lead them to new treatments.
As a substantial fraction of the TS mutations we have described either do affect widely conserved residues, or are not fast-acting, further efforts to identify additional conditional mutations in even these essential C. elegans genes may prove valuable, and TS mutations have yet to be identified for most of the roughly 2500 essential genes present in the C. elegans genome.
However, no HNPCC predisposing MSH3 mutations have yet been identified.
For hVAPB, however, such mutations have yet to be identified.
However, genotype-phenotype correlations in patients harboring these mutations have yet to be characterized.
There are many tumor types where MEK mutations have yet to be identified.
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Unfortunately, functional data remains sparse and the importance of these mutations has yet to be characterized.
However, the existence of such mutations has yet to be demonstrated.
Despite a plethora of recent reports describing the contribution of V617F to different pathologies, a comprehensive mechanism of activation of this mutation has yet to be proposed.
The identification of a causative gene mutation has yet to be achieved [ 8].
The penetrance of this E200G mutation has yet to be determined.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com